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目的为了证实血管紧张素Ⅱ受体是否参与了主动脉血管平滑肌细胞(VSMC)对机械牵张力信号的直接介导。方法(1)体外分离培养静息状态的小鼠主动脉VSMC给予血管紧张素Ⅱ刺激或血管紧张素Ⅱ受体特异性阻断剂坎地沙坦(candesar-tan)预处理后给予血管紧张素Ⅱ刺激,用Western blot法检?
Purpose To confirm whether angiotensin II receptor is involved in the direct mediation of mechanical stretch signals by aortic vascular smooth muscle cells (VSMCs). Methods (1) In vitro isolation and culture of aorta VSMC of resting mice was treated with angiotensin Ⅱ or candesar-tan, a specific antagonist of angiotensin Ⅱ receptor Ⅱ stimulation, using Western blot method?