近来讨论到用口服抗生素代替胃肠道外给药以预防心内膜炎,且口服羟氨苄青霉素可能优于青霉素 V。作者也曾报告单β次口服羟氨苄青霉素2g 比相同剂量的青霉素 V 产生较高的更持续的血清浓度,且对草绿色链球菌,羟氨苄青霉素的最小杀菌浓度≥0.12mg/l。然而在牙科操作前一小时所给的单次口服羟氨苄青霉素2g,在牙科菌血症后9小时这一关键性时间内仍 It has recently been suggested that oral antibiotics may be used instead of parenterals to prevent endocarditis, and oral amoxicillin may be superior to penicillin V. The authors have also reported that a single [beta] dose of amoxicillin 2 g produces a higher, more sustained serum concentration than the same dose of penicillin V and has a minimum bactericidal concentration> 0.12 mg / l against Streptococcus viridans, amoxicillin. However, a single oral administration of amoxicillin 2 g administered one hour prior to dental operation remained within the critical period of 9 hours after dental bacteremia