【摘 要】
：
Dear Editor,rnLung disease is a serious concern in humans and domestic animals.Huge economic losses are caused by enzootic pneumonia in the swine industry worldwide (Maes et al.,2018).The lung can be easily invaded by environmental pathogens,resulting in
【机 构】
：
State Key Laboratory of Pig Genetic Improvement and Production Technology,Jiangxi Agricultural Unive
论文部分内容阅读
Dear Editor,rnLung disease is a serious concern in humans and domestic animals.Huge economic losses are caused by enzootic pneumonia in the swine industry worldwide (Maes et al.,2018).The lung can be easily invaded by environmental pathogens,resulting in lung diseases usually accompanied by lung lesions.Environmental and genetic factors jointly affect the initiation and development of lung diseases,and there have been many genetic studies of lung diseases in humans(Hansel et al.,2013;Hobbs et al.,2017) and domestic ani-mals (Huang et al.,2017;McRae et al.,2018).However,in humans,it is difficult to assess lung lesions directly.The genetic basis of lung diseases is normally investigated by lung function testing as an indirect disease indicator (Hansel et al.,2013;Hobbs et al.,2017).In this sense,the pig can serve as an excellent human biomedical model due to its similarity to human in anatomy,physiology,and genetics.It is convenient to gain direct and accurate phenotype of lung lesions after harvesting the pigs,which is helpful in deci-phering the genetic architecture of lung diseases.
其他文献
The limited intratumoral perfusion of nitric oxide(NO)-carrying nanoparticles into solid tumors caused by the inherent bio-logical barriers in vivo greatly attenuates their generated efficacy.Herein,through entrapping heat-sensitive NO donors(BNN6)on meso
Homoeologous recombination (HR),the exchange of homoeologous chromosomes,contributes to subgenome adaptation to diverse environments by producing various phenotypes.However,the potential relevance of HR and innate immunity is rarely described in triploid
Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5％—1％annual incidence.Low molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but treatment with LMWH is invasive.Our aim i
In the comparison with SARS-CoV of 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only
The brown planthopper (BPH) (Nilaparvata lugens St(a)l) is a highly destructive pest that seriously damages rice (Oryza sativa L.)and causes severe yield losses.To better understand the physiological and metabolic mechanisms through which BPHs respond to
Male sterility is an essential trait in hybrid seed production,especially for monoclinous and autogamous food crops.Soybean male-sterile ms1 mutant has been known for more than 50 years and could be instrumental in making hybrid seeds.However,the gene res
Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in
According to an annual flagship report produced jointly by the FAO and several other organizations,almost 690 million people,or 8.9 percent of the world\'s population,were still suffering from chronic hunger in 2019 (FAO et al.,2020).Moreover,the disast
Commensal bacteria boost serum IgG production in response to oral immunization with antigen and cholera toxin(CT)in a manner that depends on Nod2(nucleotide-binding oligomerization domain-containing protein 2).In this study,we examined the role of intesti
Epidermal growth factor(EGF)has been shown to improve piglet intestinal morphology and epithelial recovery.In an attempt to further understand the mechanisms behind these improvements,this study tested the hypothesis that dietary EGF may affect intestinal