肾病综合征(NS)是以缓解、复发和对皮质激素敏感为特征。尽管延长或重复激素疗程,仍存在频繁复发的问题,长期激素治疗又可引起许多副作用。有报道,类固醇激素和环磷酰胺联用可延长 NS缓解期,但对环磷酰胺的用量和持续治疗时间尚无一致意见。而且每日应用环磷酰胺也可引起骨髓抑制、感染、出血性膀胱炎、脱发、性腺衰竭、恶性肿瘤等副作用。间歇性应用环磷酰胺冲击疗法,可减少这些 Nephrotic syndrome (NS) is characterized by its relief, relapse, and sensitivity to corticosteroids. In spite of prolonged or repeated hormone regimens, there are frequent recurring problems which, in turn, can cause a number of side effects. It has been reported that steroid hormones and cyclophosphamide can prolong the remission of NS, but there is no consensus on the amount of cyclophosphamide and duration of treatment. And daily application of cyclophosphamide can also cause bone marrow suppression, infection, hemorrhagic cystitis, hair loss, gonadal failure, malignant tumors and other side effects. Intermittent cyclophosphamide shock therapy can reduce these