POEMS(Polyneuropathy organomegaly endocr-inopathy M-proteins skin changs)综合征自1938年首次报道以来,国外类似病例日益增多,国内罕见报道。现将我院最近收治1例报告如下。 患者男性,47岁,农民。因反复四肢浮肿,进行性肌无力1年,于1992年4月2日第二次入院。患者1年前无诱因出现左下肢肿胀,继而波及右下肢及双上肢,伴四肢麻木、发胀,2个月后出现四肢肌无力,从远侧端向近侧端发展,并感周身皮肤发紧发硬,1991 Since the first report of POEMS (Polyneuropathy organomegaly endocr-inopathy M-proteins skin changs) syndrome in 1938, there are more and more similar foreign cases. Now my hospital admitted to a recent report as follows. Male patient, 47 years old, farmer. Due to repeated limb edema, progressive muscle weakness for 1 year, on April 2, 1992 second admission. Patients with unexplained left lower extremity swelling a year ago, and then spread to the right lower extremity and upper extremity, with numbness, swollen limbs, limb weakness after 2 months, from the distal to the proximal side of the development and the feeling of periventricular skin Tight and hard, 1991