Objective:Recent studies have shown the important influence of various micro factors on the general biological activity and function of endothelial cells (ECs).Vascular endothelial growth factor (VEGF) and angiogenin (ANG) are classic micro factors that promote proliferation,differentiation,and migration of ECs.The underlying pathophysiological mechanisms and related pathways of these micro factors remain the focus of current research.Data sources:An extensive search was undertaken in the PubMed database by using keywords including micro factors and endothelial cell. This search covered relevant research articles published between January 1,2007 and December 31,2018.Study selection:Original articles,reviews,and other articles were searched and reviewed for content on micro factors of ECs.Results:VEGF and ANG have critical functions in the occurrence,development,and status of the physiological pathology of ECs.Other EC-associated micro factors include interleukin 10,tumor protein P53,nuclear factor kappa B subunit,interleukin 6,and tumor necrosis factor.The results of Gene Ontology analysis revealed that variations were mainly enriched in positive regulation of transcription by the RNA polymerase Ⅱ promoter,cellular response to lipopolysaccharides,negative regulation of apoptotic processes,extal side of the plasma membrane,cytoplasm,extracellular regions,cytokine activity,growth factor activity,and identical protein binding.The results of the Kyoto Encyclopedia of Genes and Genomes analysis revealed that micro factors were predominantly enriched in inflammatory diseases.Conclusions:In summary,the main mediators,factors,or genes associated with ECs include VEGF and ANG.The effect of micro factors on ECs is complex and multifaceted.This review summarizes the correlation between ECs and several micro factors.