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本文应用大鼠全肠外营养（ＴＰＮ）模型，观察ＴＰＮ过程中表皮生长因子（ＥＧＦ）对小肠谷氨酰胺（Ｇｌｎ）摄取及肠道免疫功能的调节作用。结果显示：常规ＴＰＮ可导致血浆及各组织中Ｇｌｎ明显下降，肠粘膜淋巴细胞ＩＬ－２活性明显下降，细菌易位增高；而在ＴＰＮ过程中加用ＥＧＦ可防止肠道Ｇｌｎ水平下降，提高肠道对Ｇｌｎ的摄取率，并可有效防止肠粘膜淋巴细胞ＩＬ－２活性的下降，减少细菌易位。提示ＥＧＦ具有防止ＴＰＮ后肠粘膜屏障损伤和细菌易位作用。
In this paper, rat model of total parenteral nutrition (TPN) was used to observe the regulatory effect of epidermal growth factor (EGF) on intestinal glutamine (Gln) uptake and intestinal immune function in TPN. The results showed that: conventional TPN can lead to a significant decrease in plasma and tissue Gln, intestinal mucosal lymphocyte IL-2 activity was significantly decreased bacterial translocation increased; and in the TPN process with EGF to prevent intestinal Gln levels decreased, improve the intestine Glutamine uptake rate, and can effectively prevent the decline in intestinal mucosal lymphocytes IL-2 activity, reduce bacterial translocation. Tip EGF has to prevent TPN rear intestinal mucosal barrier damage and bacterial translocation.