【摘 要】
：
Two new diterpenes, 15-ethyl-18-methyl pinifolate (1) and 18-hydroxy-labda-8(17),13E-dien-15-acetate (2), were isolated from the needles of Pinus sylvestris. Th
【机 构】
：
Faculty of Pharmaceutical Sciences University of Tokushima,Shomachi 1-78 Tokushima 770-8505,Japan,
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Two new diterpenes, 15-ethyl-18-methyl pinifolate (1) and 18-hydroxy-labda-8(17),13E-dien-15-acetate (2), were isolated from the needles of Pinus sylvestris. Their structures were elucidated by spectroscopic methods, including 2D-NMR spectra. Compound 1 exhibited the significant cytotoxic activity against the human carcinoma cell lines Hela, SK-N-SH and BEL-7402 in vitro.
Both new diterpenes, 15-ethyl-18-methyl pinifolate (1) and 18-hydroxy-labda-8 (17), 13E-dien-15-acetate (2), were isolated from the needles of Pinus sylvestris. elucidated by spectroscopic methods, including 2D-NMR spectra. Compound 1 exhibited the significant cytotoxic activity against the human carcinoma cell lines Hela, SK-N-SH and BEL-7402 in vitro.
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