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动脉粥样硬化是发达国家的主要死亡原因。虽然目前已知的危险因素有一定的预测价值,但动脉粥样硬化发展变化的主要部分还不是很清楚。找到新的方法,对更全面地认识及治疗这个疾病是很重要的。对鞘磷脂代谢的探索就是这样一种方法。最近的研究表明鞘磷脂在动脉粥样硬化的发展过程中发挥了重要的作用。该文主要对该领域的一些主要发现进行总结。
Atherosclerosis is the leading cause of death in developed countries. Although the known risk factors have certain predictive value, the main part of the development of atherosclerosis is still not clear. Finding new ways is important for understanding and treating the disease more fully. Exploring the metabolism of sphingomyelin is one such method. Recent studies have shown that sphingomyelin plays an important role in the development of atherosclerosis. The article mainly summarizes some of the major findings in this area.