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通过结扎免冠状动脉左前降支，分析缺血心肌单相动作电位（ＭＡＰ）和心电图ＳＴ段变化的方法，观察了山莨菪碱对缺血心肌电生理的影响。结果心肌缺血５ｍｉｎ时，单相动作电位幅度（ＡＭＡＰ）、动作电位时程（ＭＡＰ９０和ＭＡＰ５０）分别降低１５． ６±３．６ｍＶ，２８．７±１２．４ｍｓ和４０．１±１３．４ｍｓ；给予莨菪碱静脉注射后，缺血５ｍｉｎ时上述各项指标的变化分别为９．３±３．４ｍＶ，２２．０±５．１ｍｓ和２３．１±７．５ｍｓ，两组之间差异明显（Ｐ＜０．０１）。缺血５ｍｉｎ时，单纯缺血组和加用山莨菪碱组的ＳＴ段偏移分别为０．３７±０．１７ｍＶ和０．２４±０．１０ｍＶ（Ｐ＜０．０１）。结果说明山莨菪碱可增加心肌对缺血的耐受力。
The effect of anisodamine on the electrophysiology of ischemic myocardium was observed by ligating left anterior descending coronary artery (LADC) and analyzing the change of single phase action potential (MAP) and electrocardiogram ST segment in ischemic myocardium. Results After 5min of myocardial ischemia, AMAP, MAP90 and MAP50 decreased 15 respectively. 6 ± 3.6mV, 28.7 ± 12.4ms and 40.1 ± 13.4ms, respectively. After given intravenous injection of scopolamine, the changes of these indexes were 9.3 ± 3.4mV and 22 .0 ± 5.1ms and 23.1 ± 7.5ms, with significant difference between the two groups (P <0.01). At 5 min of ischemia, the ST segment deviations in the ischemic and anisodamine groups were 0.37 ± 0.17 mV and 0.24 ± 0.10 mV, respectively (P <0.01). The results showed that anisodamine increased myocardial tolerance to ischemia.