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本研究采用美国国家临床实验室标准委员会（ＮＣＣＬＳ）推荐的琼脂稀释法测定７０株耐甲氧西林金黄色葡萄球菌（ＭＲＳＡ）对庆大霉素、氧氟沙星、红霉素、利福平、ＴＭＰ、ＳＭＺ／ＴＭＰ、磷霉素、壁霉素、万古霉素和去甲万古霉素等１０种抗生素的最小抑菌浓度（ＭＩＣ），以指导临床经验性抗生素的治疗。这７０株ＭＲＳＡ对９种抗生素的耐药率为庆大霉素９２９％，氧氟沙星１５７％，红霉素９５７％，利福平４００％，ＴＭＰ９４３％，ＳＭＺ／ＴＭＰ８４３％，壁霉素、万古霉素和去甲万古霉素均为０，磷霉素的ＭＩＣ５０为１２８ｍｇ／Ｌ。临床ＭＲＳＡ感染不宜选用庆大霉素、红霉素、ＴＭＰ、ＳＭＺ／ＴＭＰ、磷霉素；宜选用万古霉素、去甲万古霉素、壁霉素和氧氟沙星；在常规药敏结果的指导下选用利福平，应联合用药。
In this study, 70 strains of methicillin-resistant Staphylococcus aureus (MRSA) were tested against gentamicin, ofloxacin, erythromycin, rifampicin by agar dilution method recommended by the National Committee for Clinical Laboratory Standards (NCCLS) , TMP, SMZ / TMP, fosfomycin, penicillin, vancomycin and norvancomycin 10 antibiotics, such as the minimum inhibitory concentration (MIC), to guide the clinical experience of the treatment of antibiotics. The resistance rates of these 70 strains of MRSA to 9 antibiotics were 92.9% of gentamicin, 15.7% of ofloxacin, 95.7% of erythromycin, 40.0% of rifampicin, %, SMZ / TMP84 3%, naringin, vancomycin and norvancomycin all 0, and fosfomycin MIC50 128 mg / L. Clinical MRSA infection should not use gentamicin, erythromycin, TMP, SMZ / TMP, fosfomycin; should use vancomycin, vancomycin, naringin and ofloxacin; in the conventional susceptibility results Under the guidance of the selection of rifampicin, should be combined.