结核性脑膜炎(tubercular meningitis,TBM)主要是由于结核分枝杆菌通过血行播散沉积并破坏软脑膜或室管膜而产生的,是结核分枝杆菌感染最严重的表现形式,10%的肺结核患者可能并发结核性脑膜炎,50%患者可致死亡或遗留严重的神经系统后遗症,导致后期生活质量下降~([1])。如果患者开始治疗时格拉斯哥昏迷评分<10/15,病死率会超过50%,因此早期诊断并治疗对于减少神经系统并发症及病死 Tubercular meningitis (tuberculous meningitis, TBM) is the most serious manifestation of Mycobacterium tuberculosis infection due to Mycobacterium tuberculosis by hematogenous disseminated deposition and destruction of the pia mater or ependymal membrane, 10% of tuberculosis Patients may have tuberculous meningitis, causing death or serious neurologic sequelae in 50% of patients, leading to a decline in quality of life later (1). If the patient starts treatment Glasgow coma score <10/15, the case fatality rate will exceed 50%, so early diagnosis and treatment for reducing nervous system complications and death