目的:探讨头孢菌素类抗生素的药理特性并分析该药物的临床应用。方法:选取我市某三甲医院2015年11月至2016年11月收治的100例由于服用头孢菌素类抗生素药物出现不良反应患者的资料,并分析和研究不良反应发生的具体情况以及累及部位。结果:所有患者在服用头孢菌素类抗生素药物后,有43例患者患者出现不良反应,不良反应发生率为50%,患者累及部位主要在皮肤,神经系统以及消化系统等。结论:在服用头孢菌素类抗生素药物后,患者的皮肤,神经系统以及消化系统会出现不同程度的不良反应,因此在开具头孢菌素类抗生素药物时,要明确该药物的药理特性,并对患者的生命体征以及临床反应进行实时监测,这样才能在一定程度上降低不良反应的发生率,提升临床治疗效果。 Objective: To investigate the pharmacological properties of cephalosporin antibiotics and analyze the clinical application of the drug. Methods: The data of 100 patients who had adverse reactions due to taking cephalosporin antibiotics were selected from a top-grade hospital in our city from November 2015 to November 2016, and the specific conditions of the adverse reactions and the involved sites were analyzed. Results: All patients took cephalosporin antibiotics, 43 patients had adverse reactions, the incidence of adverse reactions was 50%, the patient involved mainly in the skin, the nervous system and digestive system. Conclusion: After taking cephalosporin antibiotics, the patient’s skin, nervous system and digestive system will have different degrees of adverse reactions, therefore, cephalosporins antibiotics should be clear when the drug’s pharmacological properties, and Patients with vital signs and clinical response to real-time monitoring, so as to a certain extent, reduce the incidence of adverse reactions and enhance clinical treatment.