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近几年对肥大细胞所作的研究可能改变关于肥大细胞的传统认识,不再将其简单地看成通过迅速释放组织胺等代谢性介质启动急性过敏反应的细胞。它除了参与急、慢性炎症反应外,还是细胞因子的一个潜在来源,这些细胞因子与白细胞的细胞因子具有协同抗感染和抗寄生虫作用。在某些IgE依赖性炎症反应中,肥大细胞可能是唯一或主要的启动器,并可影响非肥大细胞依赖机制触发的炎症。对肥大细胞概念的新认识还可能影响到疾病的治疗。
Research on mast cells in recent years has the potential to change the traditional understanding of mast cells and no longer treat them simply as cells that initiate acute allergic reactions by rapidly releasing metabolic mediators such as histamine. In addition to being involved in acute and chronic inflammatory reactions, it is a potential source of cytokines that synergize with anti-parasitic effects of leukocyte cytokines. In some IgE-dependent inflammatory responses, mast cells may be the only or primary activators and may affect inflammation triggered by non-mast cell-dependent mechanisms. New understanding of the concept of mast cells may also affect the treatment of the disease.