尽管多项研究表明 ,编码最少量细胞毒性T细胞 (CTL )抗原表位的 DNA疫苗能同时诱导对多个表位的免疫应答 ,但还未研究疫苗最优化的可能性。因此 ,作者通过实验探求与多表位 DNA疫苗免疫原性增强有关的各种因素 ,以期明确设计该类疫苗的适宜原则。　　作者进行了两项实验。第一 Although a number of studies have shown that DNA vaccines encoding the minimal epitopes of cytotoxic T-cells (CTLs) can induce immune responses to multiple epitopes simultaneously, the potential for vaccine optimization has not been investigated. Therefore, the authors sought to explore various factors related to the enhanced immunogenicity of the polytope DNA vaccine through experiments, with a view to defining the appropriate principles for designing such vaccines. The author conducted two experiments. the first