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[目的]观察奥美拉唑联合马来酸曲美布汀治疗反流性食管炎(RE)的临床疗效。[方法]58例患者随机分为2组,观察组30例,予奥美拉唑20 mg,每日2次,马来酸曲美布汀0.1 g,每日3次口服;对照组28例:予马来酸曲美布汀0.1 g,每日3次口服。疗程均8周,观察烧心、反酸、胸痛等症状,并复查胃镜下愈合率。[结果]观察组临床总有效率100%,内镜下总有效率96.7%;对照组为75.0%及71.4%,2组比较差异有统计学意义(P<0.05)。[结论]奥美拉唑联合马来酸曲美布汀治疗RE具有较好的疗效。
[Objective] To observe the clinical efficacy of omeprazole and trimebutine maleate in the treatment of reflux esophagitis (RE). [Method] 58 patients were randomly divided into two groups. The observation group consisted of 30 patients, omeprazole 20 mg twice daily and trimebutine maleate 0.1 g orally three times a day. The control group of 28 patients : Trimebutine maleate 0.1 g, 3 times a day orally. The course of treatment was 8 weeks, observed heartburn, acid reflux, chest pain and other symptoms, and review the gastroscope healing rate. [Results] The total effective rate of the observation group was 100%, the total effective rate of endoscopy was 96.7%; the control group was 75.0% and 71.4%. There was significant difference between the two groups (P <0.05). [Conclusion] omeprazole combined with trimebutine maleate in the treatment of RE has good curative effect.