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目的观察重组干扰素aIb滴眼液对翼状胬肉切除羊膜移植术后预防复发的效果。方法将105例翼状胬肉切除羊膜移植术后患者,分成50例治疗组,用重组干扰素aIb滴眼液滴眼,55例对照组用0.1%氟米龙滴眼液滴眼,两组均4~6次/d,约12d拆线,继续滴眼药水4~6周。结果术后经12~24个月,平均15个月随访,治疗组50例,无1例复发;对照组55例,复发6例,复发率10.9%,两组比较差异有显著性(P<0.05)。结论重组干扰素aIb滴眼液能很好地抑制翼状胬肉成纤维细胞的增殖及新生血管生长,是翼状胬肉切除羊膜移植术后预防复发的理想辅助药物。
Objective To observe the effect of recombinant interferon alIb eye drops on the prevention of recurrence after pterygium excision amniotic membrane transplantation. Methods 105 cases of pterygium excised amniotic membrane transplantation patients were divided into 50 treatment groups, with recombinant interferon aIb eye drops, 55 control group with 0.1% fluorometholone eye drops, both groups were 4 ~ 6 times / d, about 12d stitches, continue to eye drops 4 to 6 weeks. Results After 12 months to 24 months of follow-up, the average follow-up time was 15 months. There were 50 cases in the treatment group and none in the control group. 55 cases in the control group had recurrence in 6 cases (recurrence rate was 10.9%), the difference was significant between the two groups (P < 0.05). Conclusion Recombinant interferon aIb eye drops can effectively inhibit the proliferation and angiogenesis of pterygium fibroblasts. It is an ideal adjuvant for the prevention of recurrence after pterygium excision amniotic membrane transplantation.