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磺胺类药物(sulfonamides,SAs)是一类传统的化学合成抗菌药,在兽医临床上和畜牧业中广泛用于预防和治疗细菌感染性以及某些寄生虫疾病。由于该类药物具有独特的对氨基苯磺酰胺结构,使其能够与对氨基苯甲酸竞争二氢叶酸合成酶,从而阻止了细菌叶酸合成而起到抑菌作用[1]。该类药具有抗菌谱广、使用方便、价格低廉、性质稳定等优点,尤其是与抗菌增效剂联用后能够显著增强其抗菌活性甚至呈现杀菌作用[2];但药物使用不当会在动物体内富集,
Sulfonamides (SAs) are a class of traditional chemical synthetic antibacterials that are widely used in veterinary clinics and livestock husbandry to prevent and treat bacterial infectivity and certain parasitic diseases. Because these drugs have a unique structure of p-aminobenzenesulfonamide, which allows it to compete with p-aminobenzoic acid for dihydrofolate synthase, thereby preventing bacteriostasis from bacterial folic acid synthesis [1]. This kind of medicine has wide antibacterial spectrum, easy to use, low price, stable property and other advantages, especially when combined with antibacterial synergist can significantly enhance its antibacterial activity or even show the role of sterilization [2]; However, improper use of drugs in animals In vivo enrichment,