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目的分析强直性脊柱炎与人类白细胞相关抗原B27(HLA-B27)的相关性,为临床诊断提供参考。方法应用流式细胞术检测强直性脊柱炎患者的HLA-B27阳性率,并与正常对照组比较。结果强直性脊柱炎患者的HLA-B27阳性率为91.1%(其中男性93.9%,女性85.7%),而健康对照组为4.2%,两组比较差异有统计学意义(P<0.05)。结论HLA-B27与强直性脊柱炎强相关,检测HLA-B27对于强直性脊柱炎的早期诊断、鉴别诊断具有重要的临床价值。
Objective To analyze the correlation between ankylosing spondylitis and human leukocyte antigen B27 (HLA-B27), and to provide a reference for clinical diagnosis. Methods The positive rate of HLA-B27 in patients with ankylosing spondylitis was detected by flow cytometry and compared with the normal control group. Results The positive rate of HLA-B27 in patients with ankylosing spondylitis was 91.1% (93.9% in males and 85.7% in females), compared with 4.2% in healthy controls (P <0.05). Conclusion HLA-B27 is strongly correlated with ankylosing spondylitis. The detection of HLA-B27 has an important clinical value in the early diagnosis and differential diagnosis of ankylosing spondylitis.