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目的:通过检测迁延性腹泻婴儿血清食物特异性Ig G抗体,了解婴儿腹泻与食物不耐受的关系及饮食干预疗效。方法:分析郑州市儿童医院2010年12月~2014年1月临床表现为迁延性腹泻1~3月龄配方奶喂养婴儿病例90例,检测患者血清中14种食物过敏源特异性Ig G抗体,针对牛奶不耐受患儿予氨基酸配方或深度水解配方奶干预,出院后针对患儿是否继续进行饮食干预分为继续进行饮食干预组(干预组,51例)和随意停用或间断饮食干预组(对照组,14例),并随访半年观察疗效。结果:90例迁延性腹泻婴儿中,有68例存在食物特异性Ig G升高,阳性率为75.5%,其中存在牛奶不耐受患儿65例。出院后半年干预组较对照组体重增长良好(P<0.05)。结论:牛奶不耐受是配方奶喂养婴儿迁延性腹泻并营养不良的原因之一,牛奶不耐受患儿予游离氨基酸配方或深度水解配方奶喂养非常安全有效。
Objective: To understand the relationship between infant diarrhea and food intolerance and the effect of diet intervention by detecting serum food-specific Ig G antibody in infants with persistent diarrhea. Methods: From December 2010 to January 2014 in Zhengzhou Children’s Hospital, 90 cases of infantile infant feeding with 1 ~ 3-month postponement diarrhea were studied. 14 food allergen-specific Ig G antibodies were detected in serum of patients in Zhengzhou Children’s Hospital. For children with milk intolerance to amino acid formula or deep hydrolysis formula intervention, after discharge for the children to continue diet intervention is divided into continuing diet intervention group (intervention group, n = 51) and random stop or intermittent diet intervention group (Control group, 14 cases), followed up for six months to observe the curative effect. Results: In 90 cases of persistent diarrhea infants, 68 cases of food-specific Ig G increased, the positive rate was 75.5%, of which there are 65 cases of milk intolerance in children. Six months after discharge, the body weight of the intervention group grew better than that of the control group (P <0.05). CONCLUSIONS: Milk intolerance is one of the causes of persistent diarrhea and malnutrition in formula-fed infants. It is safe and effective for milk intolerant children to be fed either free amino acids or deep-hydrolyzed formula.