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目的 观察吡喹酮(PQT)对疑似脑囊尾蚴病患者的诊疗作用.方法 先采用间接血凝试验(IHA)和酶联免疫吸附试验(ELISA)检测疑似腩囊尾蚴病患者血清和脑脊液中的抗体,并采用夹心ELISA法检测患者血清和脑脊液中的循环抗原,再应用大剂量PQT[50 ms/(kg·d)×12 d]对疑似脑囊尾蚴病患者进行诊断性治疗.结果 93例疑似脑囊尾蚴病患者诊断性治疗后有38例确诊患脑囊尾蚴病,42例基本确诊患其他脑部疾患,13例仍诊断不明.38例脑囊尾蚴病患者有27例服吡喹酮后出现杀虫反应,其中治疗后有17例患者复查脑CT或MRI,结果 显示病灶缩小、周围水肿吸收或消失;有2例患者复查脑CT显示病灶增多,且呈囊性影像学表现;另11例确诊为脑囊尾蚴病的患者服药期间未出现杀虫反应,根据治疗后复杏CT或MRI,病灶较治疗前吸收或消失而确诊.确诊的38例脑囊尾蚴病患者再经过1～2个疗程抗囊尾蚴治疗后临床症状消失,其中31例患者复查脑CT,病灶完全吸收者26例,病灶出现钙化者5例.结论 大剂量吡喹酮对疑似脑囊尾蚴病患者具有较好的诊疗作用.“,”Objective To study the diagnostic and therapeutic effects of praziquantel (PQT) on suspected cerebral cysticerco-diagnostic therapy. Methods High doses of PQT [50mg/(kg·d)×12d] were administered to suspected cerebral cysticercosis patients for diagnostic therapy.Results Of all the 93 cases, 38 cases were definitively diagnosed as cerebral cysticercosis after the diagnostic therapy, 42 cases diagnosed as other cerebral diseases, and 13 cases still unconfirmed. Of the 38 cerebral cysticercosis cases, ad-verse reactions occurred to 27 patients during the treatment. Among these 27 cases, post-therapeutic CT and MRI revealed loci de-creased, surrounding edema was absorbed or vanished in 17 patients, but the foci increased and cystic lesions appeared in 2 pa-tients. Among the other 11 cases without adverse reactions, post-therapeutic CT or MRI revealed the loci were absorbed or dimin-ished. After additional 1-2 periods of the treatment, the clinical symptoms disappeared in 31 cases of the 38 cases definitively di-agnosed as cerebral cysticercosis, and CT revealed complete absorption of the loci in 26 cases and calcified loci in 5 cases among the 31 patients. Conclusion The therapy with high doses of PQT has effective diagnostic and therapeutic effects on suspected cerebral cysticercosis.