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[目的]观察金葵胃药(JK)对胃黏膜损伤的保护作用,并探讨其机制。[方法]采用盐酸-乙醇灌胃致大鼠胃黏膜损伤模型,观察JK用药组和对照组的胃黏膜损伤指数,并测定血清和胃组织超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平。[结果]JK(90、180、360 mg/kg)能明显降低大鼠胃黏膜损伤指数,并明显提高血清和胃组织中SOD活性,降低其MDA水平。[结论]JK对大鼠胃黏膜损伤有明显的保护作用,其作用机制可能与抗氧化作用有关。
[Objective] To observe the protective effect of Jin Kui stomach medicine (JK) on gastric mucosal injury and explore its mechanism. [Methods] Gastric mucosal injury model was induced by intragastric administration of hydrochloric acid-ethanol. The gastric mucosal injury index was observed in the JK drug group and the control group. The activity of superoxide dismutase (SOD) and malondialdehyde (MDA) in the serum and stomach tissues were measured. MDA) level. [Results] JK (90, 180, 360 mg/kg) significantly reduced the index of gastric mucosal injury in rats, and significantly increased the activity of SOD in serum and stomach tissue, and decreased its MDA level. [Conclusion] JK has obvious protective effect on gastric mucosal damage in rats, and its mechanism may be related to antioxidation.