论文部分内容阅读
目的:研究新型醒脑静中艾片有效成分龙脑在大鼠鼻腔给药和静注给药后的药代动力学。方法:醒脑静静注给药剂量为12 mg.kg-1,鼻腔给药剂量为150 mg.kg-1。采用气相色谱法测定血中龙脑的浓度,以Kinetica 4.4软件计算药代动力学参数。结果:鼻腔给药醒脑静滴鼻液后,艾片有效成分龙脑能迅速进入血液中,生物利用度可达83%。结论:鼻腔给药后龙脑能迅速而较完全地吸收进入体循环。
OBJECTIVE: To study the pharmacokinetics of a new type of brainwashing tablet, which is the active ingredient of borneol, in the nasal and intravenous administrations. Methods: Xingnao intravenous injection dose of 12 mg.kg-1, nasal administration dose of 150 mg.kg-1. The concentrations of borneol in blood were determined by gas chromatography and the pharmacokinetic parameters were calculated using Kinetica 4.4 software. Results: nasal administration of Xingnaojing nasal drops, the active ingredient of the active ingredient borneol can quickly enter the blood, the bioavailability of up to 83%. Conclusion: Nasal administration of borneol can quickly and completely absorbed into the systemic circulation.