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介绍一种可用于肝肿瘤内治疗的~(90)Y-玻璃微球(~(90)Y-GTMS),其直径为30-50μm,~(90)Y核素经反应堆中子活化生成。有BECK-MAN LS 7500β~-液体闪烁谱仪和Ge(Li)γ射线谱仪分析~(90)Y-GTMS的核纯,测定其在生理盐水中可溶出率为10~(-5)量级。家兔肝内动脉注射~(90)Y-GTMS,60min后处死。脏器分布结果表明:除了胆囊、胆管和胰腺中极少量栓塞外,肺、胃、肠、骨和骨髓均没发现有放射性,即没有肝外栓塞。~(90)Y-GTMS主要分布在肝内中部,边缘部分较少。~(90)Y-GTMS在体内有较高稳定性,可用作内介入放射性治疗。
A ~ (90) Y-glass microspheres (~ (90) Y-GTMS) with a diameter of 30-50 μm and ~ (90) Y nuclei were generated by the reactor neutron activation. The nuclear purity of ~ (90) Y-GTMS was analyzed by BECK-MAN LS 7500β ~ - liquid scintillation spectrometer and Ge (Li) γ ray spectrometer, and its dissolution rate in normal saline was determined as 10 ~ (-5) level. Rabbit intrahepatic artery was injected with ~ (90) Y-GTMS and sacrificed 60 minutes later. The results of organ distribution showed that no radioactivity was found in the lung, stomach, intestine, bone and bone marrow except for a very small amount of embolism in the gallbladder, bile ducts and pancreas. That is, there was no extrahepatic embolization. ~ (90) Y-GTMS are mainly distributed in the middle part of the liver, with fewer edge parts. ~ (90) Y-GTMS in the body has a higher stability, can be used as an endogenous interventional radiotherapy.