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Objective:To explore the difference in the anti-fatigue effect of moxibustion at different acupoints through observing the impacts of moxibustion at Shènshù1 (肾俞BL23),Zúsānlǐ (足三里ST36),Guānyuán(关元CV4) and Shénquè (神阙CV8) on energy metabolic indexes in the one-off exhausted rats.Methods:A total of 56 SPF male rats were randomized into 7 groups,named a blank group,a model group,a non-acupoint group,a BL23 group,a ST36 group,a CV4 group and a CV8 group,8 rats in each group.The one-off exhaustion model was established by weight-bearing swimming experiment.Right after the exhaustive swimming of rats in each intervention group,the mild moxibustion was applied at the corresponding acupoints for 15 min immediately.4 h after the exhaustive swimming,the blood was collected from the femoral artery and the quadriceps femoris of the left hindlimb was stripped.The levels of blood lactate (BLD),lactate dehydrogenase (LDH),creatine kinase (CK) and blood urea nitrogen (BUN),the expressions of adenosine triphosphatease (ATP),fructose-6-phosphofructokinase (PFK)and malomdialdehyde (MDA) in the quadriceps femoris and the activity of superoxide dismutase (SOD)and catalase (CAT) were detected.Results:Compared with the model group and the non-acupoint group,the levels of serum BLD,LDH,CK and BUN were all lower those in the BL23 group,the ST36 group,the CV4 group and the CV8 group,indicating a statistical significance (all P ＜ 0.05).Compared with the model group and the non-acupoint group,PFK was higher in the BL23 group,indicating a statistical significance (both P ＜ 0.05).Compared with the model group and the non-acupoint group,PFK was higher in the ST36 group and the CV4 group,indicating a statistical significance (all P ＜ 0.05).Conclusion:It was found in the research that moxibustion at BL23 ST36 CV4 and CV8 regulated the energy metabolism in the one-off exhausted rats so as to bring the anti-fatigue effect into play and the effect was different among the acupoints.Moxibustion at CV8 may work on the prevention of the protein decomposition in the skeletal muscle and moxibustion at BL23 may be against the oxidation in the skeletal muscle.