目的:提高对伴dupMLL、HOX11WT1基因阳性的急性白血病髓外浸润的认识。方法:报告1例伴dupMLL、HOX11和WT1基因阳性急性髓系白血病合并胸膜侵犯并对相关文献进行复习总结。结果:dupM-LL、HOX11和WT1基因阳性急性髓系白血病患者易并发髓外浸润,髓外侵犯部位可同时表达融合基因。结论:伴dupMLL、HOX11、WT1基因阳性的急性白血病有较高的髓外浸润率并且对常规化疗耐药,预后较差。 OBJECTIVE: To improve the understanding of extramedullary infiltration of acute leukemia with dupMLL and HOX11WT1 gene. Methods: One case was reported with dupMLL, HOX11 and WT1 gene positive acute myeloid leukemia complicated with pleural invasion and the related literature was reviewed and summarized. Results: The patients with dupM-LL, HOX11 and WT1 gene positive acute myeloid leukemia were prone to have extramedullary infiltration, and the extramedullary invasion site could express the fusion gene simultaneously. CONCLUSION: The acute leukemia with dupMLL, HOX11 and WT1 genes has a higher rate of extramedullary infiltration and is resistant to conventional chemotherapy with poor prognosis.