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Spatial pattern analysis is the core component in landscape ecology research. We analyzed the landscape pattern and dynamic process of the Kubuqi Desert by using a typical region as a study area. This study area includes four towns: ShuLinZhao, WangAiZhao, BaiNiJing and JiGeSiTai. The area of cropland, fixed sand dune, woodland, residential area and wetland increased and centralized gradually, while the area of semi-fixed sand dune, drifting sand dune, meadow and washland decreased and dispersed gradually from 1987 to 2003. On the landscape level, the patch shape tended to be regular, and the landscape pattern tended to be simple, causing the fragmentation degree, heterogeneity and diversity of the landscape to decrease. Fixed sand dune, Semi-fixed sand dune, drifting sand dune, meadow and river flood plains were the five main export classes, and residential area, cropland and wetland were the three main import classes. The classes that had a relatively large total area and large average patch area had a smaller extent of gravity center migration, whereas the classes with small total area and small average patch area had a larger extent of gravity center migration; this is because the small patches are easily influenced by human activities or natural factors. In addition, the desertifieation area and desertifieation degree reduced gradually in the study area during the period from 1987 to 2003.