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奥米拉唑(Omeprazole)为选择性 H_-~+-K_-~+-ATP 酶抑制剂。临床研究表明:其抗分泌作用强,持续时间长,停药后无胃酸分泌的反跳,副作用少而短暂,为高效、低毒、服用方便的胃酸分泌抑制剂。随着临床应用的推广,其不良反应也渐被发现,本文对此作一简述,供用药参考。1 一般反应奥米拉唑最常见的不良反应是:腹痛、腹泻、头痛、恶心、呕吐等,发生率约为20%。化验检查中最常见的副作用是谷-丙转氨酶(ALT)和谷-草转氨酶(AST)升高。65a 以下组和65a 以上组的副作用发生率相似。
Omeprazole is a selective H_ ~ ~ -K_ ~ ~ + -ATPase inhibitor. Clinical studies have shown that: its strong anti-secretory effect, long duration, no gastric acid secretion after stopping the rebound, few and short side effects, high efficiency, low toxicity, easy to take gastric acid secretion inhibitor. With the promotion of clinical application, its adverse reactions have gradually been found, this article to make a brief, for reference. 1 General reaction The most common adverse reactions of omeprazole are: abdominal pain, diarrhea, headache, nausea, vomiting, the incidence was about 20%. The most common side effects of laboratory tests are elevated levels of ALT and AST. The incidence of side effects was similar in groups 65a and 65a.