用3株小鼠和1株人的瘤株培养上清进行实验,发现均具有免疫抑制活性。抑制刀豆素A(ConA)诱导的淋巴细胞增殖;抑制白细胞介素2的产生和反应性,而对NIH3T3成纤维细胞无抑制作用。肿瘤培养上清无细胞毒作用,其抑制作用无种属特异性,是由一种(类)分子量大于9.4KD的蛋白质所致。本文对这种因子在理论及临床上的意义进行了讨论。 Experiments were performed on culture supernatants of 3 mice and 1 human tumor strain and found to have immunosuppressive activity. Inhibition of concanavalin A (ConA)-induced lymphocyte proliferation; inhibition of interleukin-2 production and reactivity, but no inhibition of NIH3T3 fibroblasts. The tumor culture supernatant had no cytotoxic effect and its inhibitory effect was not specific to the species and was caused by a protein with a (molecular weight) greater than 9.4 kD. This article discusses the theoretical and clinical significance of this factor.