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目的探讨宫颈分泌物胎儿纤维连接蛋白(fFN)检测联合Bishop评分对缩宫素引产结局的预测价值。方法前瞻性选择189例初产、头位、单胎、未破膜、有引产指征,且无母婴禁忌证的孕41~41+6周孕妇,缩宫素引产前行fFN检测及Bishop评分,并记录引产开始至分娩时间。结果 fFN阳性组3d内引产成功率明显高于阴性组(87.4%vs 25.0%,χ2=61.84,P<0.001);fFN预测引产成功的灵敏度和特异度分别为81.7%和82.3%,高于Bishop评分的63.4%和66.1%;两指标串联使用时特异度高达94.0%,误诊率降为6.0%。结论同Bishop评分法相比fFN检测可以更好的预测缩宫素引产成功与否,串联使用可以作为是否进行缩宫素引产的指征,大大降低无效引产的发生。
Objective To investigate the predictive value of cervical feline fetus fibronectin (fFN) combined with Bishop score on oxytocin induced labor. Methods 189 cases of pregnant women with first trimester, head position, single fetus, unruptured membrane, indications of induction of labor, and pregnant women with no contraindication for pregnancy 41 to 41 + 6 weeks prospectively and prostaglandin oxytocin were given prospectively. Score, and record the induction of labor to the delivery time. Results The success rate of induced labor in 3 days in fFN positive group was significantly higher than that in negative group (87.4% vs 25.0%, χ2 = 61.84, P <0.001). The sensitivity and specificity of fFN in predicting successful induction of labor were 81.7% and 82.3% The scores of 63.4% and 66.1%; two indicators in series when the specificity of up to 94.0%, misdiagnosis rate dropped to 6.0%. Conclusions Compared with Bishop’s score, fFN test can better predict the successful outcome of oxytocin induction. Serial use can be used as an indication of oxytocin induction and greatly reduce the incidence of ineffective induction of labor.