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应用放射免疫法测定了35例急性心肌梗塞(AMI)患者血浆心钠素浓度的动态变化,并探讨了与心功能改变的关系。结果表明,AMI患者发病24h,3,5,7,14天的血浆心钠素水平均高于正常对照组。动态观察14例血清丙酮酸激酶(PK),发现AMI患者在发病3天~14天的血浆心钠素水平与PK峰值及Killip心功能级别的变化密切相关。提示AMI发病3天后的血浆心钠素水平可作为反映心功能改变的指标之一。
The radioimmunoassay was used to determine the dynamic changes of plasma atrial natriuretic peptide in 35 patients with acute myocardial infarction (AMI) and to explore the relationship with cardiac function changes. The results showed that AMI patients at onset of 24h, 3,5,7,14 plasma atrial natriuretic peptide levels were higher than the normal control group. Dynamic observation of 14 cases of serum pyruvate kinase (PK) found AMI patients in the onset of 3 days to 14 days of plasma atrial natriuretic peptide levels and peak PK and Killip heart function level changes are closely related. It is suggested that the level of plasma atrial natriuretic peptide 3 days after onset of AMI can be used as one of the indexes to reflect the change of cardiac function.