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目的总结CO2气腹对肿瘤细胞侵袭性的影响以及目前的研究进展。方法复习国内外该领域的相关文献,回顾性总结CO2气腹对肿瘤细胞侵袭性的影响以及目前的研究状况。结果 CO2气腹可能通过改变间皮细胞的结构和功能、改变局部微环境、影响肿瘤细胞基因的表达、改变细胞因子分泌、改变肿瘤细胞的黏附性等机理来影响肿瘤细胞的侵袭性。结论 CO2气腹对肿瘤细胞的侵袭性确有影响,但其具体机理还有待更为深入的研究。
Objective To summarize the influence of CO2 pneumoperitoneum on tumor cell invasiveness and the current research progress. Methods Review the relevant literature in this field at home and abroad, retrospectively summarize the impact of CO2 pneumoperitoneum on tumor cell invasiveness and the current research status. Results CO2 pneumoperitoneum could affect the invasion of tumor cells by changing the structure and function of mesothelial cells, changing the local microenvironment, affecting the gene expression of tumor cells, changing the secretion of cytokines, and changing the adhesion of tumor cells. Conclusions CO2 pneumoperitoneum has an impact on the invasiveness of tumor cells, but its exact mechanism needs to be further studied.