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局部应用噻吗心安(timolol)滴眼治疗青光眼时,会使全身吸收此药,虽然,在局部用药的成年病人的血清中,发现噻吗心安的水平相当低,但临床已证明,可以发生β-阻滞症状。在正常志愿者,局部滴噻吗心安后,可观察到心率明显减少。由于眼局部滴用此药而出现心血管和支气管的副作用已常有报道。对于高血压或心脏病患者,全身用β-阻滞剂治疗,产生明显代谢影响已有报道。这些包括血清甘油三酯水平的增高,血清胆固醇、脂蛋白和游离脂肪酸的变化,已经怀疑其干扰血液离子的平衡,也干扰了血糖和尿酸的代谢。
Topical application of timolol instillation treats glaucoma and causes systemic absorption of this drug. Although timolol is found to be relatively low in serum of topical adult patients, it has been clinically proven that beta - Blocking symptoms. In normal volunteers, local drip timolol, can be observed significantly reduced heart rate. Side effects of cardiovascular and bronchial tubes have often been reported because of eye drops. For patients with hypertension or heart disease, systemic treatment with β-blockers, have a significant metabolic effects have been reported. These include elevated serum triglyceride levels, changes in serum cholesterol, lipoproteins, and free fatty acids that have been suspected to interfere with the balance of blood ions and interfere with the metabolism of blood sugar and uric acid.