目的探讨颅底肿瘤切除术后脑脊液漏的诊断和处理措施。方法对25例颅底肿瘤切除术后脑脊液漏患者的临床资料进行回顾性分析。结果大部分术后脑脊液漏患者经漏液糖含量测定即可定性,利用CT脑池造影或MRI检查确定漏口位置;约72%的患者经保守治疗和腰池引流于332d内治愈,6例(24%)并发颅内感染,1例死亡。结论术后早期积极腰椎穿刺引流脑脊液,是预防和处理术后脑脊液漏行之有效的方法;仅少数保守治疗无效者需行手术修补。 Objective To investigate the diagnosis and treatment of cerebrospinal fluid leakage after skull base tumor resection. Methods The clinical data of 25 patients with cerebrospinal fluid leakage after skull base tumor resection were analyzed retrospectively. Results Most patients with cerebrospinal fluid leakage were qualified by measuring the amount of leaking sugar. The location of the leakage port was determined by CT cerebral cava angiography or MRI. About 72% of patients were cured by conservative treatment and drainage of the waist cavity within 332 days. Six cases (24%) complicated with intracranial infection and 1 died. Conclusions Positive lumbar puncture drainage cerebrospinal fluid in the early postoperative period is an effective way to prevent and treat postoperative cerebrospinal fluid leakage. Only a small number of conservative treatment ineffective surgical repair.