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为了寻求胖细胞型星形细胞瘤正确的病理诊断和鉴别诊断,收集26例临床病理资料并进行免疫组化检测。结果显示 GFAP、S-100蛋白和 vimentin 全部阳性。8例透射电镜观察显示瘤细胞体大,核偏位呈印戒状,除含丰富细胞小器外,尚见致密成束平行排列和纵横交织的短股胶质丝。结论:本瘤诊断的3条标准:①胖细胞型星形细胞占500以上,且分化良好;②纤维型和原浆型星形细胞无间变;③具有上述免疫组化和超微结构的特点。应与易于混淆的5类肿瘤相鉴别。
In order to seek the correct pathological diagnosis and differential diagnosis of fat cell astrocytoma, 26 cases of clinicopathological data were collected and detected by immunohistochemistry. The results showed that GFAP, S-100 protein and vimentin were all positive. 8 cases of transmission electron microscopy showed large tumor cells, nuclear deviation was signet ring, in addition to containing rich small units, but also to see the dense bundles arranged in parallel and cross-woven short strands of plastic silk. CONCLUSION: The three criteria for diagnosis of this tumor include: ① fat cell type astrocytes accounting for more than 500 and well differentiated; ② fibroblast and plasma-type astrocytes are invariant; ③ have the above characteristics of immunohistochemistry and ultrastructure . Should be confused with the 5 types of tumor phase identification.