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目的 旨在观察三羧氨基喹啉 (L inomide)对人舌鳞状细胞癌裸鼠移植瘤生长的抑制效应 ,以明确 L inomide的抑瘤作用 ,为 L inomide用于人口腔鳞癌的治疗以及后续的进一步研究提供理论和实验依据 .方法 将人舌鳞癌细胞系 Tca8113接种至 BAL B/ C(nu/ nu)裸鼠 ,建立人舌癌裸鼠移植瘤模型 ,设立对照组、5 0 mg/ (kg· d)及 10 0 mg/ (kg· d) L inomide腹腔注射组 ,观察L inomide对肿瘤生长的抑制作用 .结果 与对照组相比 ,给予 Linomide治疗组的裸鼠皮下肿瘤体积明显缩小 (P<0 .0 1) ,肿瘤的生长明显受到抑制 ,10 0 mg/ (kg· d)组的瘤块体积要小于 5 0 mg/(kg· d)组的荷瘤裸鼠 (P<0 .0 1) ,说明 Linomide能抑制人舌癌裸鼠移植瘤的生长 ,且抑制程度与L inomide的剂量相关 .给予 L inomide治疗的荷瘤裸鼠其平均瘤重低于对照组 (P<0 .0 1) ,10 0mg/ (kg· d)组的荷瘤裸鼠的平均瘤重与 5 0 mg/ (kg· d)组的裸鼠比较 ,其瘤重的降低更为明显 (P<0 .0 1) .给药组裸鼠的存活时间与对照组相比明显延长 (P<0 .0 1) ,10 0 mg/ (kg· d)组的荷瘤裸鼠存活时间要长于 5 0 mg/ (kg· d)组的裸鼠 (P<0 .0 1) .结论 L inomide对人舌鳞状细胞癌裸鼠移植瘤有明显的抑瘤效应 .
The purpose of this study was to investigate the inhibitory effect of Lomomide on human tongue squamous cell carcinoma xenograft in nude mice and to determine the antitumor activity of Lomomide for the treatment of oral squamous cell carcinoma Follow-up further studies provide theoretical and experimental basis.Methods Human tongue squamous cell carcinoma cell line Tca8113 was inoculated into BALB / C (nu / nu) nude mice to establish human tongue cancer xenograft model in nude mice. The control group, 50 mg / (kg · d) and 100 mg / (kg · d) L inomide were injected intraperitoneally to observe the inhibitory effect of L inomide on tumor growth.Results Compared with the control group, the volume of subcutaneous tumors in Linomide-treated group was significantly (P <0.01). The growth of tumor was obviously inhibited. The volume of tumor mass in 10 0 mg / (kg · d) group was smaller than that in tumor-bearing nude mice of 50 mg / (kg · d) group <0 01), indicating that Linomide can inhibit the growth of xenografted human xenografts in nude mice, and the degree of inhibition is related to the dose of Lomomide.The average tumor weight of nude mice bearing L inomide is lower than that of the control <0.01). Compared with nude mice in the 50 mg / (kg · d) group, the average tumor weight of nude mice in the 10 0 mg / (kg · d) (P <0.01). The survival time of the nude mice in the administration group was significantly longer than that in the control group (P <0.01), and the survival time in the 10 mg / (kg · d) group The survival time of tumor-bearing nude mice was longer than that of nude mice of 50 mg / (kg · d) group (P0.01) .Conclusion L inomide has obvious anti-tumor effect on transplanted human tongue squamous cell carcinoma .