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目的:探讨奥沙利铂亚叶酸钙和氟尿嘧啶在晚期结直肠癌中的疗效。方法:选择我院晚期结直肠癌患者共90例,上述患者随机分为观察组和对照组。观察组给予奥沙利铂亚叶酸钙和氟尿嘧啶联合化疗。对照组给予亚叶酸钙和氟尿嘧啶化疗。评定疗效化疗效果和毒副反应发生情况。结果:观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组患者中外周神经功毒性发生率高于对照组,差异有统计学意义(P<0.05)。结论:奥沙利铂亚叶酸钙和氟尿嘧啶在晚期结直肠癌中的疗效显著,值得借鉴。
Objective: To investigate the efficacy of oxaliplatin-leucovorin and fluorouracil in patients with advanced colorectal cancer. Methods: A total of 90 patients with colorectal cancer in our hospital were selected. The above patients were randomly divided into observation group and control group. The observation group was given oxaliplatin leucovorin and fluorouracil combined with chemotherapy. Control group leucovorin and fluorouracil chemotherapy. To assess the efficacy of chemotherapy and toxic side effects. Results: The effective rate of the observation group was higher than that of the control group (P <0.05). The incidence of peripheral neurotoxicity in the observation group was higher than that of the control group (P <0.05). Conclusion: The efficacy of oxaliplatin-leucovorin and fluorouracil in patients with advanced colorectal cancer is significant and worth learning.