氨基糖甙类抗生素,在临床上广为应用的主要有链霉素、卡那霉素、庆大霉素、新霉素、妥布霉素、巴龙霉素等。这类抗生素有相似的化学结构,在抗菌机理、抗菌谱及药理作用等方面都有共同之处。它们对敏感细菌的蛋白质合成具有抑制作用,从而导致细菌死亡,故临床疗效可靠。现将其配伍用药方面的一些问题,简要叙述一下。一、氨基糖甙类抗生素,任何两种都不宜同时联用(包括同时肌注;或一种肌注,另一种静注)。由于它们的作用机理均为干扰细菌细胞内的蛋白质合成,联用时毒性相加。表现为骨骼肌松弛作用、对耳蜗毒性作用(听觉障碍)、对前庭毒性作用(前庭机能障碍)以及对肾脏毒性作用相加。二、氨基糖甙类抗生素与氯霉素(合霉素)或 Aminoglycoside antibiotics, widely used in clinics are mainly streptomycin, kanamycin, gentamicin, neomycin, tobramycin, paromomycin and so on. Such antibiotics have similar chemical structure, in the antibacterial mechanism, antimicrobial spectrum and pharmacological effects and other aspects have in common. They inhibit the protein synthesis of sensitive bacteria, resulting in bacterial death, so the clinical curative effect is reliable. Now its compatibility drug use some of the problems, a brief description. A, aminoglycoside antibiotics, any two should not be combined (including simultaneous intramuscular injection; or an intramuscular injection, another intravenous injection). Because of their mechanism of action are interfering with bacterial cell protein synthesis, when combined toxicity. It exhibits skeletal muscle relaxation, toxic effects on the cochlea (hearing impairment), effects on vestibular toxicity (vestibular dysfunction), and toxic effects on the kidneys. Second, aminoglycoside antibiotics and chloramphenicol (tetracycline) or