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克林霉素为林可霉素七位羟基被氯离子取代的半合成衍生物,具有抗菌活性强、抗菌谱广等特点,临床应用广泛。近年来有关该药不良反应的报道明显增加,其最严重不良反应是伪膜性肠炎,发生率为2%～20%[1]。在此对广州军区武汉总医院近2年来收治的克林霉素所致急性肾功能衰竭(ARF)患者的临床资料进行回顾性分析。
Clindamycin is a semi-synthetic derivative of seven lincomycin hydroxy substituted by chloride ion. It has the characteristics of strong antibacterial activity and wide antibacterial spectrum, and has wide clinical application. In recent years, reports of adverse drug reactions increased significantly, the most serious adverse reaction is pseudomembranous colitis, the incidence rate of 2% to 20% [1]. Herein, the clinical data of clindamycin-induced acute renal failure (ARF) admitted to Wuhan General Hospital of Guangzhou Military Region in recent 2 years were retrospectively analyzed.