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本文共收集临床诊断为肝癌患者的手术或肝穿肝组织7例,经组织学诊断,6例为原发性肝癌,1例为胆管癌,常规制备超薄切片标本,国产DXB2—12型电镜观察,结果分析如下: 一、核的改变及其病理学意义:肝癌细胞核呈明显多形态性,核/浆比例大,核质密度高,核仁肿大多样。但分化程度不同,核的这些结构特征表现程度亦异,增殖迅速的低分化癌,胞核更不规则,胞质细胞器更少,高分化癌则与正常肝细胞相似。表明癌细胞增殖速度、分化程度及恶性程度与形态特征存在一定关系。二、癌细胞质细胞器分布异常及其意义:中分化型肝癌形态变化更为复杂,癌细胞的主要细胞器〈如线粒体、
This article collected a total of 7 patients with liver cancer who had clinical diagnosis of liver cancer. After histological diagnosis, 6 patients had primary liver cancer and 1 patient had cholangiocarcinoma. Routine preparation of ultra-thin section specimens, domestic DXB2-12 electron microscope Observations, the results are analyzed as follows: First, the nuclear changes and their pathological significance: liver cancer cell nuclear was significantly more morphological, nuclear / slurry ratio, nuclear density, nuclear enlargement and diverse. However, different degrees of differentiation, nuclear structural characteristics of these features are also different, rapid proliferation of poorly differentiated cancer, more irregular nuclear, cytoplasmic organelles less, highly differentiated cancer is similar to normal liver cells. It shows that there is a certain relationship between the proliferation rate, differentiation degree and malignancy of cancer cells and morphological characteristics. Second, the abnormal distribution of cancer cell organelles and its significance: The morphological changes of moderately-differentiated liver cancer are more complex, the main organelles of cancer cells (such as mitochondria,