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目的：本文研究了六种查耳酮的制备方法，查耳酮是合成黄酮类化合物的中间体。方法：在氢氧化钠催化下，苯乙酮与苯甲醛反应。结果：制备了１－苯－３－（４－二甲氨基苯基）２－丙烯酮（５），１－苯－３－（３－硝基苯基）－２－丙烯酮（６），１－苯－３－（２—羟基苯基）－２－丙烯酮（７），１－苯基－３－（４－甲氧基苯基）－２－丙烯酮（８），１－（２，４—二甲氧基苯基）－３－（４－甲氧基苯基）－２－丙烯酮（９）和１－（２，４－二甲氧基苯基）－３－（３－硝基苯基）－２－丙烯酮（１０）。经ＭＳ，１ＨＮＭＲ和元素分析确定其为区标化合物。结论：本法制备查耳酮产率高，易纯化。
Objective: In this paper, six kinds of chalcone preparation methods, chalcone synthesis of flavonoids intermediates. Methods: Under the catalysis of sodium hydroxide, acetophenone reacted with benzaldehyde. Results: 1-Benzene-3- (4-dimethylaminophenyl) -2-propenone (5) (8), 1-phenyl-3- (4-methoxyphenyl) -2-propenone (2,4-dimethoxyphenyl) -3- (4-methoxyphenyl) -2-propenone (9) and 1- (3-nitrophenyl) -2-propenone (10). It was identified as a target compound by MS, 1HNMR and elemental analysis. Conclusion: The method for preparing chalcone has high yield and is easy to be purified.