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对３５例食管癌（ＥＣ）患者和３０例正常人（ＮＣ）的外周血自然杀伤（ＮＫ）细胞活性、Ｔ细胞亚群、血浆可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）、肿瘤坏死因子α（ＴＮＦ－α）以及外周血诱生γ干扰素（ＩＦＮ－γ）的水平进行了检测。结果显示，ＥＣ患者ＮＫ细胞活性明显降低（Ｐ＜０．０１）；ＣＤ８＋细胞增多（Ｐ＜０．０６），ＣＤ４＋／ＣＤ８＋细胞比值降低（Ｐ＜０．０５）；ｓＩＬ－２Ｒ明显增高（Ｐ＜０．０１）；外周血诱生ＩＦＮ－γ降低（Ｐ＜０．０５）；血浆ＴＮＦ－α升高。表明，上述指标对判断、分析ＥＣ患者细胞免疫功能状况及病变程度有较大的意义。
Natural Killer (NK) Cell Activity, T Cell Subpopulation, Plasma Soluble Interleukin 2 Receptor (sIL-2R), and Tumor Necrosis Factor in 35 Patients with Esophageal Carcinoma (EC) and 30 Normal Subjects (NC) The levels of α(TNF-α) and peripheral blood-derived interferon-γ (IFN-γ) were examined. The results showed that the activity of NK cells in EC patients was significantly lower (P<0.01); CD8+ cells were increased (P<0.06), the ratio of CD4+/CD8+ cells was decreased (P<0.05); sIL-2R was significantly higher (P<0.05). <0.01); peripheral blood induced IFN-γ decreased (P <0.05); plasma TNF-α increased. It shows that the above indicators have great significance in judging and analyzing the status of cellular immune function and lesions in EC patients.