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目前,环孢素A(CsA)已被广泛应用于器官移植的各个领域和各种自身免疫性疾病。在小儿肾脏疾病中,CsA主要用于肾移植和肾病综合征。本文重点讨论与CsA实际应用有关的药理学和临床知识。吸收CsA的吸收存在相当大的个体差异,即使同一患者吸收率也不尽相同。CsA的生物利用度F平均为30%,其范围是5～70%。胆汁排汇是促进CsA吸收和降低其生物利用度不恒定性的重要因素,所以CsA与食物同服可提高其吸收率。为使CsA的吸收良好又恒定,CsA口服制剂必须与适当饮料混合。巧克力奶最适宜,萍果汁亦可。采用其它饮料或交替使用各种饮
Currently, cyclosporin A (CsA) has been widely used in various fields of organ transplantation and various autoimmune diseases. In pediatric kidney disease, CsA is mainly used in kidney transplant and nephrotic syndrome. This article focuses on the pharmacology and clinical knowledge associated with the practical application of CsA. There are considerable individual differences in the uptake of CsA, even in the same patient. The bioavailability of CsA F averaged 30% and ranged from 5 to 70%. Accumulation of bile is to promote the absorption of CsA and reduce its bioavailability is not constant an important factor, so CsA and food with the same service can increase its absorption rate. To make CsA absorption good and constant, the CsA oral formulation must be mixed with the appropriate beverage. The most suitable chocolate milk, cider juice can be. Use other beverages or alternate drinks