肾功能不全与房颤的发病率密切相关,也会改变某些生理机制,对凝血机制造成潜在的影响。多项实验及临床研究认为肾功能不全不仅增加房颤及房颤患者血栓事件的发生,而且增加房颤患者抗凝治疗的出血风险,但并不能作为抗凝治疗的禁忌证。初始小剂量,严格控制国际标准化比率,并反复评价病人血栓及出血风险,及时谨慎的调整药物剂量将使病人受益。 Renal insufficiency and the incidence of atrial fibrillation are closely related, but also change some of the physiological mechanisms that have a potential impact on the coagulation mechanism. A number of experimental and clinical studies suggest that renal insufficiency not only increases the incidence of thromboembolic events in patients with atrial fibrillation and atrial fibrillation, but also increases the risk of bleeding from anticoagulation in patients with atrial fibrillation, but not as a contraindication to anticoagulant therapy. The initial small dose, strict control of the international standardization rate, and repeated evaluation of the risk of patients with thrombosis and bleeding, timely and cautious adjustment of drug doses will benefit the patient.