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系统性红斑狼疮(SLE)是累及全身多系统器官、具有多种自身抗体的自身免疫性疾病。随着早期诊断及时治疗生存期明显延长,病死率逐年减少,死亡的原因较以往有所变化。现将我院1993～1996年近4年内住院死亡的13例SLE做一分析,探讨近几年SLE死亡原因。1 临床资料13例死亡的患者中仅I例为男性,年龄20～65岁,均用皮质激素治疗,有4例用过免疫抑制剂,从发病确诊至死亡的生存期为8个月～11年。13例均有肾功能慢性损害,严重尿毒症者5例;有7例严重的感染,其中有4例二重感染,均合并严重的霉菌感染;有继发性糖尿病5例,多脏器功能衰竭7例,有狼疮性脑病4例,心功能衰竭6例,有多浆膜腔积液3例质血合并血小板减少9例,有1例病情已稳定9年,因妊娠死胎引产后死亡。
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systemic organs with multiple autoantibodies. With the early diagnosis and timely treatment of survival was significantly prolonged mortality decreased year by year, the cause of death than in the past have changed. In our hospital from 1993 to 1996 nearly 4 years of hospitalized 13 cases of SLE do an analysis of the causes of SLE in recent years. 1 clinical data of 13 patients died of only I case of male, aged 20 to 65 years, are treated with corticosteroids, 4 cases of immunosuppressive agents, diagnosed from the onset of death to survival of 8 months to 11 year. Thirteen cases had chronic renal damage, severe uremia in 5 cases; 7 cases of serious infection, of which 4 cases of double infection, both with severe fungal infection; 5 cases of secondary diabetes, multiple organ function 7 cases of failure, lupus encephalopathy in 4 cases, 6 cases of heart failure, pleural effusion with pleural effusion in 3 cases of blood and thrombocytopenia in 9 cases, 1 case has been stable for 9 years, died of pregnancy induced labor.