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目的:探讨胎盘生长因子(PIGF)联合子宫动脉搏动指数预测早发型子痫前期的应用效果。方法:选择嘉兴市妇幼保健院2018年3月至2019年3月收治的早发型子痫前期患者69例为观察组，其中轻度组37例、重度组32例；另选择该院2018年3月至2019年3月健康孕妇58例为对照组。比较各组血浆PIGF和子宫动脉指数变化，不同病情程度血浆PIGF和子宫动脉指数变化，及PIGF联合子宫动脉指数诊断灵敏度和特异度。结果:观察组血浆PIGF水平[(1.29±0.25)μg/L]低于对照组[(1.70±0.34)μg/L](n t＝7.816，n P<0.05)。观察组PI(1.48±0.31)、RI(0.83±0.12)和S/D(2.97±0.65)均高于对照组[(0.91±0.18)、(0.58±0.09)和(1.71±0.53)](n t＝12.357、13.071、11.823，均n P<0.05)。重度组血浆PIGF水平[(1.13±0.27)μg/L]低于轻度组[(1.45±0.23)μg/L](n t＝5.317，n P<0.05)。重度组PI(1.71±0.36)、RI(0.97±0.14)和S/D(3.45±0.71)均高于轻度组[(1.16±0.24)、(0.72±0.10)和(2.43±0.57)](n t＝7.556、8.618、6.616，均n P<0.05)。PIGF联合子宫搏动指数诊断早发型子痫前期的灵敏度和特异度高于PIGF与子宫搏动指数。n 结论:PIGF联合子宫搏动指数可预测早发型子痫前期病情，且联合检测可提高灵敏度和特异度。“,”Objective:To investigate the clinical application of placental growth factor (PLGF) combined with uterine artery pulsation index in predicting early-onset preeclampsia.Methods:From March 2018 to March 2019, 69 cases of early-onset preeclampsia in the Maternal and Child Health Hospital of Jiaxing were selected as observation group, including 37 cases in mild group and 32 cases in severe group.And 58 cases of normal pregnant women in our hospital from March 2018 to March 2019 were selected as control group.The changes of plasma PLGF and uterine artery index, the changes of plasma PLGF and uterine artery index in different degrees of illness, and the diagnostic sensitivity and specificity of PLGF combined with uterine artery index were compared between the two groups.Results:The level of plasma PLGF in the observation group was (1.29±0.25)μg/L, which was lower than that in the control group[(1.70±0.34)μg/L](n t=7.816, n P<0.05). The PI (1.48±0.31), RI (0.83±0.12) and S/D(2.97±0.65) of the observation group were higher than those of the control group[(0.91±0.18), (0.58±0.09) and (1.71±0.53)](n t=12.357, 13.071, 11.823, all n P<0.05). The level of PLGF in the severe group was (1.13±0.27)μg/L, which was lower than that in the mild group[(1.45±0.23)μg/L](n t=5.317, n P<0.05). The PI(1.71±0.36), RI(0.97±0.14) and S/D(3.45±0.71) in the severe group were higher than those in the mild group[(1.16±0.24), (0.72±0.10) and (2.43±0.57)](n t=7.556, 8.618, 6.616, all n P<0.05). The diagnostic sensitivity and specificity of PLGF combined with uterine pulsation index were higher than those of PLGF and uterine pulsation index alone.n Conclusion:PLGF combined with uterine pulsation index can predict the condition of early-onset preeclampsia, and the combination can improve the sensitivity and specificity.