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目的研究血清总胆汁酸在新生儿黄疸时浓度的变化及临床意义。方法选取49例新生儿黄疸患儿,其中生理性黄疸新生儿29例(生理组),病理性黄疸新生儿20例(病理组),别选49例健康新生儿作为对照组,对三组新生儿的血清总胆汁酸(TBA)、间接胆红素(IBIL)、总胆红素(TBIL)水平进行比较。结果对照组TBA为(9.17±0.69)μmol/L、IBIL为(11.98±2.58)μmol/L、TBIL为(19.04±3.64)μmol/L,生理组TBA为(10.34±0.86)μmol/L、IBIL为(127.68±20.58)μmol/L、TBIL为(160.98±27.68)μmol/L,病理组TBA为(31.67±9.23)μmol/L、IBIL为(201.34±24.65)μmol/L、TBIL为(251.67±29.99)μmol/L,生理组与病理组各指标水平均高于对照组,差异具有统计学意义(P<0.05)。结论新生儿黄疸采用胆红素检测的同时给予总胆汁酸检测时可利于临床对黄疸类型、胆汁淤积程度、肝细胞损伤和黄疸程度等情况进行有效的判断,从而可以有效对新生儿黄疸的早期诊治及预后,可以保证新生儿的健康。
Objective To study the changes and clinical significance of serum total bile acid in neonatal jaundice. Methods Forty nine neonates with jaundice, including 29 neonates with physiological jaundice (physiological group) and 20 neonates with pathological jaundice (pathological group), were selected as control group. 49 healthy newborns were selected as control group, Children’s serum total bile acid (TBA), indirect bilirubin (IBIL), total bilirubin (TBIL) levels were compared. Results TBA was (9.17 ± 0.69) μmol / L in control group, (11.98 ± 2.58) μmol / L in IBIL group and (19.04 ± 3.64) μmol / L in TBIL group, TBIL was (160.98 ± 27.68) μmol / L, pathological TBA was (31.67 ± 9.23) μmol / L, IBIL was (201.34 ± 24.65) μmol / L and TBIL was (251.67 ± 29.99) μmol / L, and the indexes of both physiological and pathological groups were higher than those of the control group (P <0.05). Conclusion Neonatal jaundice using bilirubin test while giving total bile acid test can be beneficial to clinical jaundice, cholestasis, degree of hepatocellular injury and jaundice, etc. to effectively judge the situation, which can be effective in early neonatal jaundice Diagnosis and prognosis, can guarantee the health of newborns.