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目的:调查不孕妇女宫颈人乳头瘤病毒(HPV)的感染率、亚型分布和年龄特征。方法:采用导流杂交法对778例不孕患者和体检的428例对照组的宫颈脱落细胞标本进行21种HPV亚型感染检测。结果:①不孕组和对照组的HPV感染率分别为9.90%和8.41%,两组间的阳性率差异无统计学意义(χ2=0.718,P>0.05)。②不孕组HPV感染21种分型中的14种亚型被检出。总的阳性样本中有89.6%(69/77)是高危亚型,HPV52最常见,其次为58、16、66和CP8304。③不孕组各年龄段HPV感染检出率差异无显著性意义(χ2=0.307,P>0.05)。结论:江门地区不孕人群的HPV感染率为9.90%,与正常人群无明显差异。不孕人群HPV感染情况与年龄无关,常见的型别为HPV52和HPV58。
Objective: To investigate the infection rate, subtypes and age characteristics of infertility women with cervical HPV. METHODS: Twenty-one HPV subtypes were detected in cervical exfoliated cells from 778 infertile women and 428 healthy controls using flow-through hybridization. Results: ① The HPV infection rates in infertility group and control group were 9.90% and 8.41%, respectively. There was no significant difference in the positive rate between the two groups (χ2 = 0.718, P> 0.05). ② infertility group HPV infection in 21 types of 14 subtypes were detected. Of the total positive samples, 89.6% (69/77) were high risk subtypes. HPV52 was the most common, followed by 58, 16, 66 and CP8304. (3) There was no significant difference in the detection rate of HPV infection among different age groups (χ2 = 0.307, P> 0.05). Conclusion: The HPV infection rate of infertile population in Jiangmen area is 9.90%, which has no significant difference with normal population. Infertility HPV infection has nothing to do with age, common types are HPV52 and HPV58.