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作者调查了8个家庭15例甲状腺功能正常病人,发现一种最近才认识的综合征——“家族性白蛋白异常性高甲状腺素血症”(familial dysalbuminemichyperthyroxinemia,FDH)。本病过去可误认为甲状腺功能亢进症。10例未患病亲属与20例甲状腺功能正常者作对照组。结果总血浆甲状腺素(TT_4)浓度在 FDH 病人中为15.0～24.0μg/dl,明显高于对照组(8.1±1.1μg/dl);而游离甲状腺素指数(FT_4I)则前者为7.3±1.0,亦明显高于后者(3.1±0.4)。总血浆 T_3浓度在 FDH 病人为177±41ng/dl,明显高于对照组(141±27ng/dl;P<0.01)。但经过平衡透析后发现,游离 T_3的百分率稍下降。两组游离 T_3浓度基本相等。
The authors investigated 15 familial patients with normal thyroid function in eight families and found a recently recognized syndrome, familial dysalbuminemia hyperthyroidism (FDH). The disease in the past can be mistaken for hyperthyroidism. Ten non-affected relatives and 20 normal thyroid function as control group. Results The concentration of total thyroxine (TT_4) in patients with FDH was 15.0 ~ 24.0 μg / dl, which was significantly higher than that of the control group (8.1 ± 1.1 μg / dl), while the FT_4I was 7.3 ± 1.0. Also significantly higher than the latter (3.1 ± 0.4). The total plasma T_3 concentration in FDH patients was 177 ± 41ng / dl, which was significantly higher than that in the control group (141 ± 27ng / dl; P <0.01). However, after balanced dialysis found that the percentage of free T_3 decreased slightly. Two groups of free T_3 concentrations were basically equal.