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流行病学提示,近50%的男性一生中可能患有前列腺炎,其发病机制不明,但临床治疗一般以抗生素为主,辅以扩血管、镇痛、热疗、中药内服或坐浴等对症支持。为了探讨前列腺炎的病因和筛选药物,国内外学者对动物进行了广泛的模型研究:细菌、化学物质、自身或外来免疫原皆可导致急性或慢性前列腺炎。现对其动物模型的制作方法及病理表现予以综述。
Epidemiology suggests that nearly 50% of men may have prostatitis in their lifetime, but its pathogenesis is unknown. However, the clinical treatment is generally based on antibiotics, which is accompanied by vasodilation, analgesia, hyperthermia, traditional Chinese medicine orally or bathing and other symptomatic diseases stand by. In order to explore the etiology and screening of prostatitis drugs, domestic and foreign scholars conducted a wide range of animal models: bacteria, chemicals, self or foreign immunogen can cause acute or chronic prostatitis. Now its animal model of production and pathological performance are reviewed.